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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]
2018;20 Suppl 1:5-21
A mitochondrial and a cytoplasmic isozyme are both produced from the same mRNA, most likely by alternative initiation of translation
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